ZBrush is software rendered, your choice of GPU will not matter so long as it supports the recommended monitor resolution of minimum 1280×1024 RAM: 2048MB to 6 GB recommended.
- CPU: Pentium D or newer or equivalent AMD Athlon 64 X2 or newer
- RAM: 2048MB required for working with multi-million-polys. 6 GB recommended
- Pen Tablet: Wacom or Wacom compatible
- Monitor: 1280×1024 monitor resolution or higher (32 bits)